Category Archives: Brain

Target for Addictions Identified Deep in the Brain

“Man becomes cigarette smoker. Man suffers from stroke. Man completely loses urge to smoke.”

This sums up the neon lights that have been blinking nonstop in the media around the scientific paper, “Damage to the Insula Disrupts Addiction to Cigarette Smoking” that was published in the January 26, 2007 issue of Science magazine (pages 531-534). The magazine also ran a commentary, “Brain Damage Sheds Light on Urge to Smoke” on the paper.

The key? A brain region called the insular cortext, or insula, deep within the cerebral cortex. This region has been implicated in other addictions, including cocaine addiction. Signals that trigger this region has been linked to the stimulation of addictive desires. This means insula is a potential therapeutic target – in other words – drugs or treatments that affect insula’s ability to stimulate addictive desires become a therapy for addiction. Continue reading

Interview on Self-Injury

Dr. Jane Chin: What are the biggest misconceptions or “myths” people have about self-injury?

Dr. Deborah Serani: I’d have to say that the biggest misconception about self-injury is that most people think that those who cut or self-injure are suicidal. Though any behavior that puts a person in harm’s way requires clinical evaluation, the basic reason individuals cut or self-harm comes from the wish “to control” or to “numb away feelings.”

Dr. Chin: Why is cutting or self injury such a difficult subject for people to talk about?

Dr. Serani: There is a lot of shame associated with this behavior. Seeing the scars or scabs serves as reminder to the person that they cannot find a better way to move through pent up feelings. They feel like they have failed or are flawed in some way, which exacerbates there negative feelings even more. Continue reading